During the last decade, Cell-Penetrating Peptides (CPPs) have been investigated for their ability to overcome the cell membrane barrier for the intracellular or transcellular delivery of cargoes, such as many low molecular weight drugs, imaging agents, peptides, oligonucleotides, proteins and colloidal carriers such as liposomes and polymeric nanoparticles. Their ability to cross biological plasma membranes, especially in a non-disruptive way without apparent toxicity is highly desired for increasing drug bioavailability. Attempts have been made to extract related structural information that would predict mechanism of the uptake process of the transport peptides. For example, positive charges in side chains of Arg/Lys, presence of Trp or Phe residues in certain positions, amphiphilicity of the peptide, and length of the polypeptide chain have been proposed as important factors determining cellular uptake. However, despite numerous studies carried out in the field, the mechanism of uptake of CPPs is still not clarified. Therefore, rational design of novel transport peptides, such as comparison of positive-charges-containing CPPs and neutralized form CPPs, sequence of cationic amino acid residues and the role of clustering of net positive charges will be necessary for successful application of CPPs in research and therapy.
The mechanisms of living cells can be difficult to grasp, can you provide white paper sources or books which would familiarize the reader with the environment in which the mystery is happening?
Originally Posted by sherrycd
Also, did you have a question about the subject or speculations about its uses?
Unfortunately our friend @sherrycd is a spammer trying to spread propaganda on-line for profit.
Is that what that is, another Money making scheme That suckz
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